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This reprint, organized with the recent publications of the Special Issue Antimicrobial and Anti-infective Activity of Natural Products in the journal Antibiotics, is a collection of the recent advances in the discovery of new antimicrobial compounds from natural products, mechanisms of action of pure compounds, in silico evidence of antimicrobial activity, synergistic associations with antibiotics, compounds with antiviral activity or capable of neutralizing bacterial resistance to antibiotics, as well as in vivo studies to demonstrate the effectiveness of compounds.
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