Biodegradable in Situ Microparticles for Sustained Protein Delivery (Paperback) (ISBN-13: 9783639076592)

The objective of this work was to evaluate the suitability of in situ forming biodegradable microparticles for the controlled delivery of proteins. Particular goals were: a) to evaluate the flexibility of the release patterns of in situ implant and in situ microparticle formulations using hen egg white lysozyme as model protein; b) to characterize, if and how the integrity of the model protein is affected by formulation ingredients, the manufacturing process, sto-rage of the ISM and the release from the formulations; c) to optimize protein delivery from in situ forming implant and microparticle systems, with regard to shape and completeness of the release; d) to find / validate reliable methods allowing to extract and thus to characterize the model protein in biodegradable in situ formulations.

Author: Martin Körber
ISBN-10: 3639076591
ISBN-13: 9783639076592
Publisher: VDM Verlag Dr. Mueller E.K.
Language: English
Published: 08/22/2008
Pages: 332
Format: Paperback
Weight: 0.98lbs
Size: 9.00h x 6.00w x 0.69d