Biopharmaceuticals (Paperback) (ISBN-13: 9783639136067)

In the biopharmaceutical industry, essentially, there are three components that play the main role in producing biopharmaceutical products, the host cell, the expression vector and the bioreactor and/or production environment. To produce the highly valued and desired products, the choice of a suitable host is one of the most important aspects. The host required is not only required to produce the desired product, but also needs to demonstrate robustness in a bioreactor system. Constantly facing challenges in a bioreactor, cells often undergo apoptosis, a well-known limiting factor in biopharmaceutical production, which ultimately leads to low yield of valuable protein(s). We have genetically engineered a CHO-K1 cell line to constitutively express human insulin-like growth factor-1 (IGF-1) and murine polyoma large T-antigen (PyLT-Ag) to generate Super-CHO and CHO-T respectively, two cell lines that can potentially serve different niches in the biopharmaceutical industry.

Author: Nico Wanandy
ISBN-10: 3639136063
ISBN-13: 9783639136067
Publisher: VDM Verlag
Language: English
Published: 03/18/2009
Pages: 264
Format: Paperback
Weight: 0.86lbs
Size: 9.00h x 6.00w x 0.60d