Carbohydrate-Based Vaccines and Immunotherapies (Hardcover) (ISBN-13: 9780470197561)

The fundamental science and the latest developments in carbohydrate-based vaccines

The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments.

With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids. The text approaches vaccine design from a chemical and molecular focus, staying in line with current advances.

Key topics covered by Carbohydrate-Based Vaccines and Immunotherapies include:

• Recent developments towards clinically useful vaccines against bacteria, viruses, parasites, and fungi
• Using adjuvants to improve immunogenicity and/or immunological properties of vaccines
• Choosing and designing proper adjuvants for specific targets
• Abnormal carbohydrates expressed by tumors
• Carbohydrate-based therapeutic cancer vaccines or cancer immunotherapy
• Clinical trials results for synthetic cancer vaccines
• Glycoengineering of cell surface carborhydrates and its anticancer applications
• Using cell surface carbohydrates for disease diagnosis

A single, convenient source of state-of-the-art information from leading authorities in the field, Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.