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In this reprint, we collected 17 high-quality and innovative papers investigating several factors that have contributed to the clinical complexity of COVID-19: from host-pathogen interactions to different clinical manifestations, including the impact on healthcare systems and post-COVID-19 consequences. Moreover, several articles published in this reprint focus on the post-disease and long-term effects of COVID-19, including the quality of life of the hospitalized or non-hospitalized patients, and the physical, psychological, and social effects of the pandemic.
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