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This reprint collects multidisciplinary research articles focused on Clostridioides difficile infection. The contributions collected here shed some light on grey areas of our knowledge of Clostridioides difficile, including the identification of Clostridioides difficile carriers at high risk of developing infection or infection recurrence, the intra-hospital and community spread of Clostridioides difficile, the rate of Clostridioides difficile infection during the SARS-CoV-2 pandemic, the current treatment approach, and the use of bezlotoxumab to prevent infection recurrence.
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