Computational Glioscience (Hardcover) (ISBN-13: 9783030008154)

Part 1. Introduction.- A Neuron-Glial perspective for computational neuroscience.- Part 2. Calcium dynamics.- Data-driven modelling of the inositol trisphosphate receptor and its role in calcium induced calcium release.- Intracellular calcium dynamics: biophysical and simplified models.- Modeling of stochastic Ca2+ signals.- G protein-coupled receptor-mediated astrocytic Ca2+ signaling in astrocytes.- Emergence of regular and complex calcium oscillations by inositol 1,4,5-trisphosphate signaling in astrocytes.- Astrocyte networks and intercellular calcium propagation.- Part 3. Tripartite Synapse and regulation of network activity.- Tripartite synapses and regulation of synaptic plasticity.- Purinergic signaling at tripartite synapses.- Gliotransmitter exocytosis and its consequences on synaptic transmission.- Computational models of pathophysiological glial activation in CNS disorders.- Part 4. Homeostasis and Metabolic coupling.- The role of astrocytes in neurotransmitter uptake and brain metabolism.- Glutamate uptake.- Astrocytic ion dynamics: Implications for potassium buffering and liquid flow.- Constraint-Based Modeling of Metabolic Interactions in and between Astrocytes and Neurons.- Part 5. Computational Tools to Analyze and Model Astrocyte Experiments.- Computational models of astrocytes and astrocyte-neuron interactions: Characterization, reproducibility, and future perspectives.- GECIquant: semi-automated detection and quantification of astrocyte intracellular Ca2+ signals monitored with GCaMP6f.- Modeling neuron-glia interactions with the Brian 2.0 simulator.

Author: Maurizio de Pittà
ISBN-10: 3030008150
ISBN-13: 9783030008154
Publisher: Springer
Language: English
Published: 01/31/2019
Pages: 505
Format: Hardcover
Weight: 1.99lbs
Size: 9.21h x 6.14w x 1.13d