Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism: Volume 542 (Hardcover) (ISBN-13: 9780124166189)

Volume 542 of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research methods providing a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation.

Author: Lorenzo Galluzzi
ISBN-10: 0124166180
ISBN-13: 9780124166189
Publisher: Academic Press
Language: English
Published: 05/27/2014
Pages: 536
Format: Hardcover
Weight: 2.30lbs
Size: 9.10h x 6.10w x 1.20d