Cortical Electrical Stimulation in Epilepsy Surgery (Paperback) (ISBN-13: 9783639263084)

Evaluation of neuronal responses to single-pulse electrical stimulation (SPES) was performed to determine the reliability of cortical stimulation under general anaesthesia compared to alert awareness. Nine patients with intractable epilepsy, candidates for epilepsy surgery, underwent SPES during both electrode implantation and telemetry recording. Early, delayed, repeated, fixed and oscillatory neuronal responses to SPES were investigated. Analysis showed that: a) early responses are normal markers of synaptic efficacy, b) delayed responses are markers of epileptogenicity, c) repeated responses are normal variants of deep cortical stimulation, d) fixed responses are markers of normal connectivity underlying sensory processing functions, and e) oscillatory responses are normal markers of pacemaking capability of deep brain structures. This study produced evidence that the main pathological markers have a high correlation between implantation and telemetry SPES procedures. Results render SPES an equally reliable process under both anaesthesia and alert awareness.

Author: Vasileios Kokkinos
ISBN-10: 3639263081
ISBN-13: 9783639263084
Publisher: VDM Verlag
Language: English
Published: 06/08/2010
Pages: 132
Format: Paperback
Weight: 0.45lbs
Size: 9.00h x 6.00w x 0.31d