Cytochrome P450 2e1: Its Role in Disease and Drug Metabolism (Hardcover) (ISBN-13: 9789400758803)

The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.

Author: Aparajita Dey
ISBN-10: 9400758804
ISBN-13: 9789400758803
Publisher: Springer
Language: English
Published: 02/27/2013
Pages: 256
Format: Hardcover
Weight: 1.55lbs
Size: 9.20h x 6.20w x 0.80d