Drug Metabolism and Transport: Molecular Methods and Mechanisms (Paperback) (ISBN-13: 9781617374944)

A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.

Author: Lawrence H. Lash
ISBN-10: 1617374946
ISBN-13: 9781617374944
Publisher: Humana
Language: English
Published: 11/09/2010
Pages: 388
Format: Paperback
Weight: 1.29lbs
Size: 9.00h x 6.00w x 0.89d