Effect of nebivolol, carvedilol and metoprolol on doxorubicin-cardiotox (Paperback) (ISBN-13: 9783659435652)

A comparative study of cardio protective activity of nebivolol, carvedilol and metoprolol was carried out on doxorubicin-induced cardiac toxicity in rats. The degree of protection was assessed both in vivo by short axis echocardiography measuring ejection fraction (EF), fractional shortening (FS), left ventricular systolic diameter (LVSD) and left ventricular diastolic diameter (LVDD) and in vitro by measuring the inotropic and the chronotropic responses to isoproterenol. Also histopathlogical study was done. This study revealed that there is a significant improvement of cardiac functions in rats treated with β-blockers and there is no significant difference between carvedilol and nebivolol whereas nebivolol has the best histopathological score for improvement cardiac toxicity.

Author: Sayed Eman, Khattab Aida Abdallah, El-Aziz Sadek Sawsan Abd
ISBN-10: 3659435651
ISBN-13: 9783659435652
Publisher: LAP Lambert Academic Publishing
Language: English
Published: 05/06/2015
Pages: 148
Format: Paperback
Weight: 0.50lbs
Size: 9.00h x 6.00w x 0.34d