Electrostatic Considerations in Mitosis: Integrating Physics and Cell Biology in Mitosis (Hardcover) (ISBN-13: 9781440173769)

Identifying the motive force is central to explaining chromosome motions during mitosis. Presently, there is no consensus on what it is. The author has proposed a minimal assumptions model for the dynamics of post-attachment chromosome motions based on nanoscale electrostatics. Given the electrical properties of tubulin and the dynamic instability of microtubules, it is possible to account for prometaphase post-attachment, metaphase, and anaphase chromosome motions within a comprehensive model. The model addresses all of the following in a unified manner:

• Efficiency of aster and spindle assembly and the motive force for the motion of asters and forming half-spindles.
• Chromatid pair attachment.
• Motion of monovalently attached chromatid pairs.
• Motion of bivalently attached chromatid pairs and chromosome congression.
• Metaphase chromatid pair oscillations.
• Chromatid separation and anaphase-A chromosome motion.
• Anaphase-B pole separation.
• An ab-initio calculation of the maximum tension force exerted by a microtubule during mitosis that falls within the experimental range.
• Poleward force generation of chromosomes at poles with associated microtubule flux.

Author: L. John Gagliardi
ISBN-10: 1440173761
ISBN-13: 9781440173769
Publisher: iUniverse
Language: English
Published: 10/29/2009
Pages: 124
Format: Hardcover
Weight: 0.75lbs
Size: 9.00h x 6.00w x 0.44d