Evolutionary conserved features of FG repeats that allow the formation of hydrogel-based perme-ability barriers with NPC-like properties (Paperback) (ISBN-13: 9783954044917)

Non-globular FG domains constitute the permeability barrier of nuclear pore complexes (NPCs), which control all macromolecular exchange between nucleus and cytoplasm. Whilst objects smaller than 30kDa can passively diffuse across this barrier, larger molecules need to be chaperoned by nuclear transport receptors (NTRs). However, the modus operandi and, inextricably linked, the exact physical nature of the NPC permeability barrier are still controversially discussed. Whereas so far, most studies exclusively focused on yeast or vertebrate FG domains, the ability of FG domains from different species to form selective barriers was explored here. Interestingly, all studied species contain 'cohesive' FG domains that interact with each other to form a characteristic (hydrogel) phase mimicking the permeability properties of NPCs.

Author: Hermann Broder Schmidt
ISBN-10: 3954044919
ISBN-13: 9783954044917
Publisher: Cuvillier
Language: English
Published: 08/23/2013
Pages: 172
Format: Paperback
Weight: 0.47lbs
Size: 8.27h x 5.83w x 0.37d