Extended Release Tablet of Glipizide (Paperback) (ISBN-13: 9786202815109)

The present investigation was to formulate and evaluate extended release tablet of glipizide using natural gum for the treatment of type II diabetes. Extended release tablet was prepared by employing hydrophobic diluents (DCP) and hydrophilic diluents (starch). Experimental work done: Preformulation studies and drug excipient profile were carried out for glipizide and dammar gum. Different batches of glipizide extended release tablets were prepared by using dicalcium phosphate and starch as diluents by wet granulation technique and direct compression method. Seven batches were made by changing concentration of dammar gum and change diluents in formulation. A physicochemical properties of dammar gum were evaluated such as acid value, iodine value, melting point, molecular weight. Result and Discussion: Results of preformulation study were satisfactory as no interaction was observed between glipizide and dammar gum by FTIR and DSC. All the pre and post compression parameters were tested. In vitro drug release profiles were examined, and compared with marketed product. The drug release of D5 batch is extended upto 98.22% in 12hr, and it follows korsmeyer peppas model.

Author: Shreya Pandya, Pooja Dave, Naisarg Pujara
ISBN-10: 6202815108
ISBN-13: 9786202815109
Publisher: LAP Lambert Academic Publishing
Language: English
Published: 09/18/2020
Pages: 108
Format: Paperback
Weight: 0.37lbs
Size: 9.00h x 6.00w x 0.26d