Genomic diversity of Escherichia coli, associated with Bacteremia (Paperback) (ISBN-13: 9783659607080)

The genomic contents of 10 clinical bloodstream infection-associated E. coli strains, isolated at the Leicester Royal Infirmary were investigated in this study. Approaches used to investigate the genomic contents of these strains were: sequential PCR strategy, and the Microarray-Assisted mobilome Prospecting (MAmP). The study proved that such strategies are successful in addressing and identifying mobilome-rich strains. Therefore, using such approaches in combination with whole genome sequencing projects could prioritize the strains and the genomic regions that need to be sequenced. Such prioritization would avoid sequencing of hundreds of isolates to identify their novel gene pool and would reduce the cost of genomic sequencing. Moreover, applying such approaches for the identification of new virulence genes and/or pathogenic mechanisms could lead to significant improvements in the treatment of E. coli infections.

Author: Bin Thani Ali
ISBN-10: 3659607088
ISBN-13: 9783659607080
Publisher: LAP Lambert Academic Publishing
Language: English
Published: 10/02/2014
Pages: 188
Format: Paperback
Weight: 0.62lbs
Size: 9.00h x 6.00w x 0.43d