Immunological investigation of autoimmune bullous dermatoses (Paperback) (ISBN-13: 9786208187873)

Autoimmune bullous dermatoses (ABD) are specific autoimmune diseases of the skin and mucous membranes. They are characterized by the presence of autoantibodies (auto-Ab) directed against skin and mucous membrane adhesion molecules, leading to altered function of their antigenic targets, resulting in clinical bullae and/or erosions. Depending on the site of cleavage, a distinction is made between intra-epidermal DBAI, characterized by auto-Ac directed against the structural proteins of the desmosomes that hold the keratinocytes of the epidermis together; and sub-epidermal DBAI, characterized by the presence of auto-Ac directed against the components of the dermo-epidermal junction (DEJ).The diagnosis of DBAI is based on clinical, histopathological and immunological evidence (detection of circulating or tissue-deposited auto-Ac). Direct immunofluorescence (DIF) is an immunological technique performed on cryosections of peri-lesional biopsies, based on the detection of Ac deposits and/or complement fractions using specific fluorescein-conjugated Ac.

Author: Ameni Jerbi
ISBN-10: 6208187877
ISBN-13: 9786208187873
Publisher: Our Knowledge Publishing
Language: English
Published: 10/16/2024
Pages: 52
Format: Paperback
Weight: 0.20lbs
Size: 9.00h x 6.00w x 0.12d