In Silico Methods for Predicting Drug Toxicity (Hardcover) (ISBN-13: 9781071619599)

1. QSAR Methods

Giuseppina Gini

Part I: Modeling a Pharmaceutical in the Body

2. PBPK Modeling to Simulate the Fate of Compounds in Living Organisms

Fr馘駻ic Y. Bois, Cleo Tebby, and C駘ine Brochot

3. Pharmacokinetic Tools and Applications

Judith C. Madden and Courtney V. Thompson

4. In Silico Tools and Software to Predict ADMET of New Drug Candidates

Supratik Kar, Kunal Roy, and Jerzy Leszczynski

Part II: Exploiting Toxicity Data for Modeling Purposes

5. Development of In Silico Methods for Toxicity Prediction in Collaboration between Academia and the Pharmaceutical Industry

Manuel Pastor, Ferran Sanz, and Frank Bringezu

6. Emerging Bioinformatics Methods and Resources in Drug Toxicology

Karine Audouze and Olivier Taboureau

Part III: The Use of In Silico Models for the Specific Endpoints

7. In Silico Prediction of Chemically-Induced Mutagenicity: A Weight of Evidence Approach Integrating Information from QSAR Models and Read-Across Predictions

Enrico Mombelli, Giuseppa Raitano, and Emilio Benfenati

8. In Silico Methods for Chromosome Damage

Diego Baderna, Ilse Van Overmeire, Giovanna J. Lavado, Domenico Gadaleta, and Birgit Mertens

9. In Silico Methods for Carcinogenicity Assessment

Azadi Golbamaki, Emilio Benfenati, and Alessandra Roncaglioni

10. In Silico Models for Developmental Toxicity

Marco Marzo, Alessandra Roncaglioni, Sunil Kulkarni, Tara S. Barton-Maclaren, and Emilio Benfenati

11. In Silico Models for Repeated-Dose Toxicity (RDT): Prediction of the No Observed Adverse Effect Level (NOAEL) and Lowest Observed Adverse Effect Level (LOAEL) for Drugs

Fabiola Pizzo, Domenico Gadaleta, and Emilio Benfenati

12. In Silico Models for Predicting Acute Systemic Toxicity

Ivanka Tsakovska, Antonia Diukendjieva, and Andrew P. Worth

13. In Silico Models for Skin Sensitization and Irritation

Gianluca Selvestrel, Federica Robino, and Matteo Zanotti Russo

14. In Silico Models for Hepatotoxicity

Claire Ellison, Mark Hewitt, and Katarzyna Przybylak

15. Machine Learning Models for Predicting Liver Toxicity

Jie Liu, Wenjing Guo, Sugunadevi Sakkiah, Zuowei Ji, Gokhan Yavas, Wen Zou, Minjun Chen, Weida Tong, Tucker A Patterson, and Huixiao Hong

Part IV: Platforms for Evaluating Pharmaceuticals

Author: Emilio Benfenati
ISBN-10: 1071619594
ISBN-13: 9781071619599
Publisher: Humana
Language: English
Published: 02/22/2022
Pages: 680
Format: Hardcover
Weight: 2.80lbs
Size: 10.10h x 7.30w x 1.60d