Influence of Natural and/or Vaccine Immunity on the Dynamics of SARS-CoV-2 (Hardcover) (ISBN-13: 9783725868308)

This Special Issue, "Influence of Natural and/or Vaccine Immunity on the Dynamics of SARS-CoV-2", published in Vaccines, examines how immunity acquired through natural infection, vaccination, or both shapes SARS-CoV-2 transmission, reinfection, variant spread, and pandemic dynamics. Hosted in the Epidemiology and Vaccination section, it provides a multidisciplinary forum to advance understanding of immune protection in an evolving pandemic. It emphasizes that SARS-CoV-2 immunity is dynamic rather than binary, influenced by factors such as prior exposure, vaccine type and dosing, immune waning, viral variants, hybrid immunity, and host characteristics. The emergence of immune-evasive variants, particularly within the Omicron lineage, highlights the need to clarify how different forms of immunity affect clinical outcomes and population-level patterns. Contributions address mechanisms of humoral and cellular immunity, comparisons between natural, vaccine-induced, and hybrid immunity, variant-specific immune escape, reinfection and vaccine effectiveness, host factors modifying immune responses, and modeling studies linking immunity to transmission and public health policy. Article types include original research, reviews, short communications, and editorials, all peer reviewed. The Special Issue underscores the importance of integrating immunological, clinical, and epidemiological evidence to inform vaccine strategies and public health decision making.