Inhibition of Angiogenesis by Potential Chemopreventive Agents (Paperback) (ISBN-13: 9783639036305)

A new human in vitro anti-angiogenesis assay was established and applied to identify novel angiopreventive agents. Subsequently, two chemopreventive compounds, xanthohumol (XN) from Humulus lupu-lus L. (hop) and sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables (Brassicaceae), were selected for detailed in-vestigation of their angiopreventive potential and mechanisms invol-ved in the inhibition of angiogenesis. Representative targets included effects at the transcriptional levels of pro-angiogenic factors, anti-gelatinolytic and anti-endothelial activity. In vivo, XN was shown to exhibit a strong anti-tumour potency on human breast cancer xeno-grafts mediated by the inhibition of tumour-induced angiogenesis. These findings strongly suggest that XN and SFN represent attractive chemopreventive lead structures possessing a remarkable potential to prevent tumour development.

Author: Elisabeth Klenke
ISBN-10: 3639036301
ISBN-13: 9783639036305
Publisher: VDM Verlag Dr. Mueller E.K.
Language: English
Published: 06/04/2008
Pages: 132
Format: Paperback
Weight: 0.41lbs
Size: 9.00h x 6.00w x 0.28d