Metallothionein (Hardcover) (ISBN-13: 9783764358303)

Metallothionein nomenclature and structure.- Nomenclature of metallothionein: Proposal for a revision.- Metallothionein: Molecular evolution and classification.- Structural and biological studies on native bovine Cu, Zn-metallothionein-3.- Circular dichroism, emission, and exafs studies of Ag(I), Cd(II), Cu(I), and Hg(II) binding to metallothioneins and modeling the metal binding site.- Metallothionein structure update.- Simulation of Zn/Cd binding in mammalian metallothionein domains.- The growth inhibitory activity of metallothionein-3 correlates with its novel ? domain sequence rather than metal binding properties.- Recombinant synthesis and metal-binding abilities of mouse metallothionein 1 and its ?- and ?-domains.- Biochemical characterization of monomeric and dimeric cadmium-substituted metallothionein-3.- Chemical and analytical aspects of metallothionein.- Mammalian metallothionein sub-isoform separation by RP-HPLC with on-line UV and electrochemical detection.- Characterisation of mammalian Cd, Zn metallothioneins using differential pulse polarography.- Comparison of CZE and MECC separations of MT isoforms.- Synthetic peptides and domains of metallothionein for structure function studies: rabbit liver peptide MT-IIA 49-61 and lobster MT ?N ?C and ?C?N domains.- Voltammetric methods in isolation and identification of plant metallothioneins from alga Chlorella.- Characterization of isometallothioneins in Chang liver cells and the transient accumulation of metallothionein and glutathione during cell proliferation.- Quantification of cytosolic metallothionein contents by a developed assay system using immobilized antibody.- Protein engineering of metallothionein to study on the metal-binding ability.- Metal binding proteins: Molecular engineering of improvements in metal specificity.- Molecular splicing of metallothionein - study on domains of metallothionein.- Metallothionein in non-mammalian tissues.- Involvement of metallothionein in female squirrelfish reproduction.- Accumulation of untranslated metallothionein mRNA in antarctic hemoglobinless fish (icefish).- Structure and function of metallothionein isoforms in terrestrial snails.- Functional and regulatory aspects of teleost metallothionein.- Metallothionein induction in mussels exposed to a metal mixture.- Synthesis and properties of class III metallothioneins of Schizosaccharomyces pombe in response to cadmium and zinc.- Phytochelatins (class III metallothioneins) and their desglycyl peptides induced by cadmium in root cultures of Rubia tinctorum L..- Chemical and spectroscopic properties of copper metallothionein from the copper resistant fungus Beauveria bassiana.- Transcription factors.- Metallothionein facts and frustrations.- Liver degeneration and embryonic lethality in mouse null mutants for the metal-responsive transcriptional activator MTF-1.- New insights into the mechanisms of cadmium regulation of mouse metallothionein-I gene expression.- Activation of mouse metallothionein I promoter by cadmium in human neuroblastoma cells.- Transcription factors involved in heavy metal regulation of the human metallothionein-IIA gene.- Transcriptional regulation of the gene encoding mouse metallothionein-3 and its expression in the organs of the reproductive system.- Dynamic regulation of yeast metallothionein gene transcription via metalloregulatory signaling factors.- Metal regulation of mammalian metal responsive element (MRE) binding proteins.- Metallothionein and hormone responsiveness.- Synergistic activation of mouse metallothionein-I gene by interleukin-6 and glucocorticoid.- Hammerhead ribozymes mediated down-regulation of rat metallothionein mrnas expression.- Inactivation of metal-induced metallothionein gene expression by protein kinase C inhibitor.- Cadmium-induced metallothionein expression and metallothionein mRNA in mice.- Role of metallothionein in reproduction, development and cell proliferation.- The nuclear-cytoplasmic presence of metallothion...

Author: Curtis D. Klaassen,Curtis Klassen,C. D. Klassen
ISBN-10: 3764358300
ISBN-13: 9783764358303
Publisher: Birkhauser
Language: English
Published: 04/24/2002
Pages: 700
Format: Hardcover
Weight: 2.87lbs
Size: 9.61h x 6.69w x 1.50d