Metronidazole Extended Release Solid Dosage Form (Paperback) (ISBN-13: 9783659355899)

Currently two effective ways are used with the administration of a metronidazole composition. A single, large dose is given as a bolus to the patient which is clinically effective but a major drawback to the administration of single large dose of metronidazole is the occurrence of significant and undesirable side effects. A second and more generally accepted treatment entails orally administering smaller dose of metronidazole three time a day. The lower dosage of metronidazole over a period of a week significantly reduces the occurrence and severity of side effect but patient compliance is a problem can inadvertently forget to take one or more doses during the course of treatment, causing the plasma metronidazole level drop to bellow an acceptable therapeutic level for a period of several hours or more. Hence extended release formulation of metronidazole could be suitable alternative for reducing the number of daily doses needed to treat a microbial infection, while maintaining the benefit of making bioavailable effective amount of drug over an extended time period.

Author: Al-Mamun MD Abdullah-, Ahmed Taksim, Kundu Sukalyan Kumar
ISBN-10: 3659355895
ISBN-13: 9783659355899
Publisher: LAP Lambert Academic Publishing
Language: English
Published: 03/02/2013
Pages: 184
Format: Paperback
Weight: 0.61lbs
Size: 9.00h x 6.00w x 0.42d