Mouth Dissolving Tablet of Olanzapine by Solid Dispersion Technique (Paperback) (ISBN-13: 9783659133084)

In the present investigation, solid dispersion of olanzapine has been prepared to improve its solubility. Further, using solid dispersion, mouth dissolving tablet was prepared to overcome the problem of swallowing. A Simplex Lattice design was applied using three factors, i.e. superdisintegrants like croscarmellose sodium(X1) crospovidone(X2), and sodium starch glycolate(X3) in tablet formulation. Disintegration time, Wetting time, Water absorption, T50 (Time required to 50% drug release) and Q10 (percentage of drug released in 10 min.) taken as responses. Solid dispersion showed significant enhancement in solubility of olanzapine. For mouth dissolving tablet, batch containing 5% croscarmellose sodium alone had minimum disintegration time (44 sec.) and faster drug release(T50: 40 sec) compared to other batches.

Author: Vishal Brahmbhatt, Natvarlal Patel, Mukesh Patel
ISBN-10: 3659133086
ISBN-13: 9783659133084
Publisher: LAP Lambert Academic Publishing
Language: English
Published: 05/22/2012
Pages: 136
Format: Paperback
Weight: 0.46lbs
Size: 9.00h x 6.00w x 0.32d