New route to the synthesis of chiral 1,2,4-oxadiazin-5-ones (Paperback) (ISBN-13: 9786207924332)

The research work carried out in this book aims to develop a simple and rapid synthesis route for new chiral derivatives of 1,2,4-oxadiazin-5-ones known for their interesting biological activities.The first part of this book describes the synthesis of a series of optically active α-bromoacids by enantioselective nitrous deamination of natural amino acids. These will subsequently react with thionyl chloride followed by methanol to give the corresponding α-bromoesters.Condensation of these previously prepared α-bromoesters with 1-benzenesulfonylpyrrolidin-2-carboxamidoxime in the presence of two equivalents of sodium hydride offers desired new chiral 1,2,4-oxadiazin-5-ones in good chemical yields.

Author: Najeh Tka
ISBN-10: 6207924339
ISBN-13: 9786207924332
Publisher: Our Knowledge Publishing
Language: English
Published: 08/08/2024
Pages: 56
Format: Paperback
Weight: 0.21lbs
Size: 9.00h x 6.00w x 0.13d