Non-Myeloablative Allogeneic Transplantation (Hardcover) (ISBN-13: 9780792376460)

Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

Author: Asad Bashey
ISBN-10: 0792376463
ISBN-13: 9780792376460
Publisher: Springer
Language: English
Published: 02/28/2002
Pages: 216
Format: Hardcover
Weight: 1.16lbs
Size: 9.52h x 6.42w x 0.70d