Pharmacokinetics and Metabolism in Drug Design (Hardcover) (ISBN-13: 9798887403755)

Pharmacokinetics (PK) determines the outcome of substances which are administered in the human body and involves drug absorption, distribution, metabolism, and excretion (ADME) processes. Drug absorption is the movement of drug in the bloodstream from its site of administration. It depends on multiple factors, including the formulation and chemical properties of a drug, drug-food interactions and route of administration. Drug distribution is essential for determining drug efficacy and drug toxicity. Drug metabolism is the chemical alteration of the drug by the body. Genetics, age and drug interactions are some factors that affect drug metabolism. In clinical use, an enzyme named cytochrome P450 (CYP450) is responsible for the biotransformation or metabolism of all drugs. It is essential to comprehend the basic mechanisms governing the pharmacokinetics of a drug for designing personalized course of therapy for patients. This book provides comprehensive insights into the role of pharmacokinetics and metabolism in drug design. It is appropriate for students seeking detailed information in this area of study as well as for experts.

Author: Erica Helmer
ISBN-10: 8887403759
ISBN-13: 9798887403755
Publisher: American Medical Publishers
Language: English
Published: 09/26/2023
Pages: 244
Format: Hardcover
Weight: 1.90lbs
Size: 11.00h x 8.50w x 0.63d