Pharmacology of the Wnt Signaling System (Paperback) (ISBN-13: 9783030855017)

Pharmacological thinking in WNT signaling.- Controlling WNT Signaling Specificity and implications for targeting WNTs pharmacologically.- WNTs on exosomes.- Strategies to target LRPs in WNT signaling.- Targeting the receptor tyrosine kinase ROR1 by small molecules.- Assessing WNT binding and Frizzled activation employing genetically encoded, biophysical sensors.- Disheveled proteins as crucial mediators of WNT signaling.- Destruction complex and regulation of CTNNB1.- Strategies to therapeutically target WNT/PCP like signaling in disease.- Mining natural compounds to target WNT signaling - from mushrooms to corals.- FZD7 as a therapeutic target in intestinal cancer.- Targeting oncogenic WNT signaling with WNT derived peptides.- Targeting WNT signaling in lung pathology.- The role of WNT signaling in osteoarthritis and the therapeutic potential of its pharmacological targeting.- WNT signaling in Alzheimers disease and other neurodegenerative disorders - opportunities for therapy?.- Targeting WNT signaling as a risk.


Author: Gunnar Schulte
ISBN-10: 3030855015
ISBN-13: 9783030855017
Publisher: Springer
Language: English
Published: 10/30/2022
Pages: 422
Format: Paperback
Weight: 1.33lbs
Size: 9.21h x 6.14w x 0.88d