Protein Termini Part a: Volume 718 (Hardcover) (ISBN-13: 9780443414831)

Protein termini represent a major route to protein regulation. From the moment the very first amino acid of a polypeptide chain exits the ribosome there is potential for steering from the cellular environment. This volume of Methods in Enzymology Modifications and Targeting of Protein Termini focuses on Protein N-termini and C-termini and their modifications which include acetylation, arginylation, myristoylation and oxidation. Also, the impact of terminal modifications is covered, in particular the impact on protein turnover and the ubiquitin E3 ligases which specifically recognize protein N-termini (N-degrons) and C-termini (C-degrons). In addition to the detailed methods and laboratory protocols, the chapters include informative overviews and reviews of the different subfields.

Author: Thomas Arnesen
ISBN-10: 0443414831
ISBN-13: 9780443414831
Publisher: Academic Press
Language: English
Published: 09/01/2025
Pages: 412
Format: Hardcover