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This Special Issue is in honor of Professor Roderick Melnik, who has pioneered many advanced mathematical models and has significantly contributed to this field over the past few decades. This Reprint is dedicated to the recent advancements, developments, and challenges pertaining to the development of current state-of-the-art models focused on mathematical and computational sciences, with their applications in relation to modeling natural, social, and engineering systems. We believe that this Reprint will provide the readers with ample knowledge and lead to the generation of novel ideas for future advancement, pushing the boundaries of knowledge in mathematical and computational sciences and their multifaceted applications.
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