Regulation of the Krüppel-like Factor 6 Tumor Suppressor (Paperback) (ISBN-13: 9783639103359)

KLF6 is a ubiquitously expressed Krüppel-like transcription factor whose role in vitro and in vivo role has not been fully identified. Like other members of the Krüppel-like family, KLF6 contains a conserved C-terminal three zinc finger DNA-binding domain (C2H2 motifs) and a unique N-terminal transactivation domain. KLF6 directly binds DNA at GC box promoter elements. Transcriptional targets of KLF6 include collagen 1, transforming growth factor beta 1 (TGFβ1), types I and II TGFβ receptors, urokinase type plasminogen activator (uPA), and the human immunodeficiency virus long terminal repeat (HIV-1 LTR). Here, we identify a novel mechanism of carcinogenesis, whereby oncogenic Ras signaling enhances alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinomas. These Ras-dependent splice forms are shown to abrogate KLF6-mediated growth suppression, and ectopic KLF6 splice variant expression can restore a Ras-transformed phenotype.

Author: Steven Yea,Scott L. Friedman
ISBN-10: 3639103351
ISBN-13: 9783639103359
Publisher: VDM Verlag
Language: English
Published: 11/06/2008
Pages: 168
Format: Paperback
Weight: 0.51lbs
Size: 9.00h x 6.00w x 0.36d