Reverse Transcriptase Inhibitors in HIV/AIDS Therapy (Paperback) (ISBN-13: 9781617376955)

A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world.

Author: Gail Skowron
ISBN-10: 1617376957
ISBN-13: 9781617376955
Publisher: Humana
Language: English
Published: 11/19/2010
Pages: 528
Format: Paperback
Weight: 1.74lbs
Size: 9.00h x 6.00w x 1.21d