Role of Capsaicin in Oxidative Stress and Cancer Diet & Cancer 3 (Hardcover) (ISBN-13: 9789400763166)

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

Author: Sanjay K. Srivastava
ISBN-10: 9400763166
ISBN-13: 9789400763166
Publisher: Springer
Language: English
Published: 05/07/2013
Pages: 178
Format: Hardcover
Weight: 0.95lbs
Size: 9.20h x 6.00w x 0.50d