Stereoselective Syntheses of Tetrahydropyrans: Applications to the Synthesis of (+)-Leucascandrolide A, (+)-Dactylolide and (ｱ)-Diospongin a (Paperback) (ISBN-13: 9783319356754)

In his thesis, Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans (THP). Readers gain insight into the new methods Lee employs for the synthesis of biologically interesting natural products including (+)-leucascandrolide A, (+)-dactylolide, and ( )diospongin A. The reactions Lee investigates are applicable to a broad range of substrates and proceed with excellent stereoselectivity. Moreover, the methodologies allow the synthesis of a wide range of THP-containing compounds. The development of reactions, such as those discussed by Lee, has the potential to impact natural product synthesis, pharmaceutical development and chemical biology.

Author: Kiyoun Lee
ISBN-10: 3319356755
ISBN-13: 9783319356754
Publisher: Springer
Language: English
Published: 09/03/2016
Pages: 184
Format: Paperback
Weight: 0.65lbs
Size: 9.21h x 6.14w x 0.44d