Targeting Cytoplasmic Tyrosine Kinases in Cancer (Paperback) (ISBN-13: 9786138392491)

Protein kinases are critical regulators of cell signaling and represent one of the most successful classes of drug targets in oncology. Among them, cytoplasmic tyrosine kinases (CTKs) play a pivotal role in controlling cell growth, survival, and differentiation. This review provides a comprehensive overview of CTKs as therapeutic targets, with a particular focus on the c-Abl kinase and its oncogenic counterpart, Bcr-Abl, in Chronic Myeloid Leukemia (CML). A significant portion of the review is dedicated to the development and clinical evolution of Bcr-Abl inhibitors, from first-generation ATP-competitive drugs like imatinib to second- and third-generation agents designed to overcome resistance. Finally, we discuss the clinical landscape of kinase inhibitors and future perspectives, positioning the Bcr-Abl story as a paradigm for targeted cancer therapy.

Author: Ahmed Abd El-Kader
ISBN-10: 6138392493
ISBN-13: 9786138392491
Publisher: Noor Publishing
Language: English
Published: 10/06/2025
Pages: 56
Format: Paperback
Weight: 0.19lbs
Size: 9.00h x 6.00w x 0.13d