Teratogenicity Testing: Methods and Protocols (Hardcover) (ISBN-13: 9781493978823)

Part I: Introduction to Teratology Testing

1. An Overview of Teratology

Ana M. Calado and Maria dos Anjos Pires

2. Teratology Study Guidelines: An Overview

Sofia Alves-Pimenta, Luís Félix, Bruno Colaço, Paula A. Oliveira, and Carlos Venâncio

3. Biological Concerns on the Selection of Animal Models for Teratogenic Testing

Sofia Alves-Pimenta, Bruno Colaço, Paula A. Oliveira, and Carlos Venâncio

Part II: In Vitro-Based Teratology Screening

4. The Validated Embryonic Stem Cell Test with Murine Embryonic Stem Cells

Lauren M. Walker, Darcie L.V. McClelland-Descalzo, and Nicole I. zur Nieden

5. Human Pluripotent Stem Cells to Assess Developmental Toxicity in the Osteogenic Lineage

Joseph V. Madrid, Steven R. Sera, Nicole R.L. Sparks, and Nicole I. zur Nieden

6. Chick Embryonic Cardiomyocytes Micromass System for Assessing Developmental Cardiotoxicity of Drugs

Wasay M.S. Qureshi and Margaret K. Pratten

7. Flow Cytometry to Evaluate Potential Developmental Toxicants in the Embryonic Stem Cell

Valéria Maria Lara, Kelly C. Santos Roballo, André Tadeu Gotardo, and Carlos Eduardo Ambrósio

8. Morphology-Based Whole Embryo Culture for Developmental Toxicity of Drugs

Bo Liang and Chi C. Wang

9. Western Blot Methodologies for Analysis of In Vitro Protein Expression Induced by Teratogenic Agents

Carlos Martins-Gomes and Amélia M. Silva

10. Manipulation of MicroRNAs in Cultured Mouse Embryos: Applications for Developmental Toxicology

Fuqiang Yuan and Shao-yu Chen

Part III: Animal-Based Teratology Methods

11. Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans

Caralina M. de Evsikova

12. Effect of Teratogens on Development of Drosophila melanogaster

Dong Li and Xiaolin Bi

13. Cellular Responses in Drosophila melanogaster Following Teratogen Exposure

Matheus C. Bianchini, José L.R. Portela, Robson L. Puntel, and Daiana S. Ávila

14. Behavioral Teratogenesis in Drosophila melanogaster

Monalisa Mishra and Bedanta Kumar Barik

15. Evaluation of the Teratogenicity of Pharmaceuticals Using FETAX

Hariz Islas-Flores, Itzayana Pérez-Alvaréz, and Leobardo M. Gómez-Oliván

16. Histological Observation of Teratogenic Phenotypes Induced in Frog Embryo Assays

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Author: Luís Félix
ISBN-10: 1493978829
ISBN-13: 9781493978823
Publisher: Humana
Language: English
Published: 06/13/2018
Pages: 614
Format: Hardcover
Weight: 2.92lbs
Size: 10.24h x 7.39w x 1.50d