The Blood-Brain Barrier: Methods and Protocols (Hardcover) (ISBN-13: 9781071622889)

Part I: Introduction to Blood-Brain Barrier (BBB) Physiology

1. Cells of the Blood-Brain Barrier: An Overview of the Neurovascular Unit in Health and Disease

Heather L. McConnell and Anusha Mishra

2. In Vitro Models of the Blood-Brain Barrier

Snehal Raut, Aditya Bhalerao, Behnam Noorani, and Luca Cucullo

Part II: Using Pluripotent Stem Cells in Models of the BBB

3. In Vitro Models of the Human Blood-Brain Barrier Based on Human Induced Pluripotent Stem Cells: Opportunities and Challenges

Iqra Pervaiz and Abraham J. Al-Ahmad

4. Induced Pluripotent Stem Cell (iPSC)-Derived Endothelial Cells to Study Bacterial-Brain Endothelial Cell Interactions

Eric R. Espinal, S. Jerod Sharp, and Brandon J. Kim

5. An hiPSC-Derived In Vitro Model of the Blood-Brain Barrier

Mary Goodwin-Trotman, Krushangi Patel, and Alessandra Granata

6. A Three-Dimensional Brain-on-Chip Using Human iPSC-Derived GABAergic Neurons and Astrocytes

Lumei Liu, Youngmi Koo, Teal Russell, and Yeoheung Yun

Part III: Co-Culture, Permeability, and Transwell Models of the BBB: Methods for Studying Shear Stress, Barrier Integrity and Breakdown

7. An Improved In Vitro Porcine Blood-Brain Barrier Model for Permeability Screening and Functional Studies

Adjanie Patabendige

8. Establishment of an In Vitro Model of Human Blood-Brain Barrier to Study the Impact of Ischaemic Injury

Rais Reskiawan A. Kadir, Mansour Alwjwaj, and Ulvi Bayraktutan

9. A Novel Dynamic Human In Vitro Model for Studying the Blood-Brain Barrier

10. A Dynamic, In Vitro BBB Model to Study the Effects of Varying Levels of Shear Stress

Gemma Molins Gutierrez, Jordi Martorell, Antonio G. Salazar-Martin, and Mercedes Balcells

Part IV: Microfluidic and Chip Models of the BBB

11. Novel, Emerging Chip Models of the BBB and Future Directions

Paul M. Holloway

12. Integrating Primary Astrocytes in a Microfluidic Model of the Blood-Brain Barrier

Eliana Lauranzano, Marco Rasile, and Michela Matteoli

13. Fabrication of Microtube-Embedded Chip to Mimic Blood-Brain Barrier Capillary Vessels

Dilshan Sooriyaarachchi, Shahrima Maharubin, and George Z. Tan

14. BBB-on-a-Chip: Modeling Functional Human BBB by Mimicking 3D Brain Angiogenesis Using Microfluidic Chip

Somin Lee, Minhwan Chung, and Noo Li Jeon

Part V: Models

Author: Nicole Stone
ISBN-10: 1071622889
ISBN-13: 9781071622889
Publisher: Humana
Language: English
Published: 06/24/2022
Pages: 357
Format: Hardcover
Weight: 1.90lbs
Size: 10.00h x 7.00w x 0.88d