The Ontogenesis of Cortical Circuitry: The Spatial Distribution of Synapses in Somesthetic Cortex of Newborn Dog (Paperback) (ISBN-13: 9783540047971)

The ontogenesis of cortical circuitry is the subject of the investigation reported in this paper!. Strategie elements of cortical circuitry are synaptic contacts: sites of neuronal interaction. If we first determine the location of early formed synap- ses, we may then seek the pre-and postsynaptic elements, that is, the structures which meet and interact at each synaptic junction. The dynamic aspects of cortical development cannot be studied directly: neuronal growth cannot be observed in an intact brain. The pattern of develop- ment can be approached only by the analysis of static properties at multiple ages. We have selected the newborn dog as a starting point for these studies. Our observations have been restricted to a small portion of primary somesthetic cor- tex. This region was selected because, in mature cortex, its input and physiologie properties are relatively weIl known. It is particularly advantageous to study a primary sensory projection area because its morphologie development can be di- rectly related to its functional development. (A related investigation of the onto- genesis of electrical activity in somesthetic cortex of the dog will be reported separately). A selective review of the literature is necessary in order to place this work in the context of a few relevant phenomena of cortical development.

Author: M. E. Molliver,H. Van Der Loos
ISBN-10: 3540047972
ISBN-13: 9783540047971
Publisher: Springer
Language: English
Published: 01/01/1970
Pages: 54
Format: Paperback
Weight: 0.24lbs
Size: 9.61h x 6.69w x 0.12d