The Smoothened Receptor in Cancer and Regenerative Medicine (Hardcover) (ISBN-13: 9783319197548)

Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins.- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators.- Receptor modifications in Hedgehog regulation.- Smoothened, stem cell maintenance and brain diseases.- Medulloblastoma, pediatric brain tumors and Smoothened blockade.- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization.- Implications in stem cell maintenance.- Comparison of the crystal structure of Smoothened to known GPCRs structure.

Author: Martial Ruat
ISBN-10: 3319197541
ISBN-13: 9783319197548
Publisher: Springer
Language: English
Published: 07/08/2015
Pages: 210
Format: Hardcover
Weight: 1.07lbs
Size: 9.21h x 6.14w x 0.56d