Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy (Paperback) (ISBN-13: 9781617377365)

Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim- ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF- has been linked to several diseases. For instance, the effect ofTGF- on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF- has a very complicated role in cancer that is only beginning to be understood.

Author: Sonia B. Jakowlew
ISBN-10: 1617377368
ISBN-13: 9781617377365
Publisher: Humana
Language: English
Published: 11/19/2010
Pages: 786
Format: Paperback
Weight: 3.05lbs
Size: 10.00h x 7.00w x 1.62d