Understanding Amyotrophic Lateral Sclerosis: Causes and Management (Paperback) (ISBN-13: 9786208420321)

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder marked by muscle weakness, atrophy, fasciculations, and spasticity due to motor neuron degeneration. Symptoms progress from focal weakness to difficulties in speaking, swallowing, and breathing, with eventual paralysis. The disease arises from mechanisms such as disrupted RNA metabolism (e.g., TDP-43 and FUS mutations), cytoskeletal and axonal transport defects (e.g., PFN1, TUBA4A mutations), excitotoxicity, and oxidative stress. While incurable, treatments like Riluzole and Edaravone can modestly slow progression, and supportive care-such as non-invasive ventilation, feeding tubes, and physical therapy-helps manage symptoms. Emerging therapies, including gene and RNA-targeted approaches, hold promise for the future.

Author: Mona El-Banna
ISBN-10: 6208420326
ISBN-13: 9786208420321
Publisher: LAP Lambert Academic Publishing
Language: English
Published: 01/10/2025
Pages: 60
Format: Paperback
Weight: 0.21lbs
Size: 9.00h x 6.00w x 0.14d