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This unique work presents one of the most significant organ failure condition - cardiocirculatory shock - and the prominent role of Methylene Blue (MB). Through their extensive experience, the authors' consider that the lifesaving feature of MB is still underestimated. For this reason they outline key concepts of MB, mentioning essential experimental data, yet focusing mainly on its application in the care of critically ill patients.
In an easy-to-read format, the 18 chapters were organized in a didactically structured order, distributed in four parts. The first part introduces the general conceptual aspects and physiology of the endothelium. The second part presents the particularities of endothelial dysfunction in different types of shock. Methylene blue is discussed in detail in the third part. In the fourth part, particular situations of endothelial dysfunction, such as heart surgery and organ transplantation, are described. Additionally, the two complementary subjects of acid-base balance and the therapeutic use of inhaled nitric oxide are mentioned.
Finally, looking for therapeutic alternatives for what we classify as "vasoplegic endothelial dysfunction", MB remains promising as an adjuvant to sympathomimetic amines. The combination of three recently proposed concepts may be useful in obtaining better results against the high mortality rates in critically ill patients. These three concepts are "wide-spectrum vasopressors", vasopressor economy strategies, and microcirculation protection against the harmful effects of using high concentrations of amines.
This book s translational approach will appeal to a variety of readers within the health specialties of medicine, biomedicine, physiotherapy, nursing, odontology, and basic science.
Paulo Roberto Barbosa Evora
Graduated in Medicine from the Ribeir縊 Preto School of Medicine, University of S縊 Paulo - USP (1972). At the same institution, he completed residencies in General Surgery (1973) and Thoracic and Cardiovascular Surgery (1974), and a PhD also in General Surgery (1980). Dr. Evora was Coordinator of the Endothelial Function Laboratory of the Experimental Surgery Division and Collaborating Researcher in Cardiovascular Surgical Research at the Mayo Clinic, Rochester, MN, USA. Associate Professor (1994) and Full Professor (2004) of the Department of Surgery, Orthopedics and Traumatology at the Ribeir縊 Preto School of Medicine, USP (1993), clinical director of the Intensive Care Center at the Hospital das Cl匤icas of the Ribeir縊 Preto School of Medicine - USP, Coordinator of the postgraduate program (2004-2006), Vice-Head of the Department (2004-2006), Head of the Department (2007-2008), member of the Research Committee of the Ribeir縊 Preto School of Medicine, and member of the Bioterio Central Commission of the USP Ribeir縊 Preto Campus, and Editor-in-chief of the Brazilian Journal of Cardiovascular Surgery.
Andrea Carla Celotto
Graduated in Biomedicine from the University of Franca (2002), obtained a Master's degree in Pharmaceutical Sciences from the Faculty of Pharmaceutical Sciences of Ribeir縊 Preto, University of S縊 Paulo - USP (2005), and completed a PhD in Sciences at the Ribeir縊 Preto School of Medicine - USP (2009). She also completed a PhD internship at the Vascular Biology Laboratory at Mayo Clinic, Rochester, MN, USA and a post-doctorate at the Endothelial Function Laboratory of the Department of Surgery and Anatomy at Ribeir縊 Preto School of Medicine - USP (2013). Former professor at the University of Franca, Dr. Celotto is currently a professor of the Faculty of Health Sciences of Barretos Dr. Paulo Prata and an Associate Researcher of the Department of Surgery and Anatomy, Ribeir縊 Preto School of Medicine - USP. She has extensive experience in Physiology, Pathophysiology and Pharmacology.
Agnes Afrodite Sumarelli Albuquerque
Bachelor's degree in Biological Sciences from Universidade Estadual Paulista J伃io de Mesquita Filho, Jaboticabal campus (2005) and specialization in Genetic Engineering and Molecular Biology (2009). She obtained a Master's degree (2012) and completed a PhD (2018) in Morphology and Experimental Medicine Surgical Clinic. Laboratory Technician at the Department of Surgery and Anatomy of the Ribeir縊 Preto Medical School of the University of S縊 Paulo.
Patricia Martinez ノvora
Graduated in Veterinary Medicine from the Universidade Estadual Paulista J伃io de Mesquita Filho, Jaboticabal campus (2008). Completed internships at Ohio State University, Columbus, OH, USA, in the fields of equine medical clinic and Molecular Biology (2008). She obtained a Master's degree in Veterinary Medicine (2012) and completed a PhD in Animal Pathology from the Universidade Estadual Paulista J伃io de Mesquita Filho, Jaboticabal campus (2017). Dr. ノvora is currently a postdoctoral fellow in Immunoparasitology at the Ribeir縊 Preto School of Medicine - USP.
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